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How does hydroxyurea therapy alleviate the symptoms of sickle cell anemia? Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to reduce the frequency of painful episodes. It raises the level of HbF and the haemoglobin level. It usually decreases the rate of painful episodes by 50 %. It was first tested in sickle cell disease in 1984.
Is hydroxyurea a cytotoxic drug? Hydroxyurea is an anti-cancer ("antineoplastic" or " cytotoxic ") chemotherapy drug. Hydroxyurea is classified as an "antimetabolite." (For more detail, see "How Hydroxyurea Works" section below).
What does hydroxyurea treat? Hydroxyurea is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck). Hydroxyurea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia.
Is hydroxycarbamide chemotherapy? Hydroxycarbamide (Hydrea) is a chemotherapy drug. It is used to treat chronic myeloid leukaemia and other cancers, such as cervical cancer. Your cancer doctor, nurse, or pharmacist will tell you how often you will have it. Like all chemotherapy drugs, hydroxycarbamide can cause side effects.
How often do you take hydroxyurea? Adults and children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. At first, 20 milligrams (mg) per kilogram (kg) once a day. Your doctor may adjust your dose as needed.
Does age affect cancer? Age is the biggest single risk factor for cancer. Risk increases significantly after age 50, and half of all cancers occur at age 66 and above. Bone cancer, for example, is most frequently diagnosed in people younger than 20, and neuroblastoma is more common in children than in adults.
Is it necessary to have radiation after lumpectomy? DCIS usually is treated with surgery to remove the cancer -- lumpectomy in most cases. Routine radiation therapy after DCIS was common in the past, but some newer DCIS treatment guidelines say that women at low-risk for recurrence may be able to skip radiation therapy after surgery.
Is chemotherapy always necessary for breast cancer? Chemotherapy may be recommended for some women diagnosed with early-stage breast cancer if the cancer is hormone-receptor-negative and HER2-positive. Chemotherapy usually is NOT recommended for non-invasive, in situ cancers such as DCIS because they have very little risk of spreading to other parts of the body.
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