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In addition, there was no significant increase in the rates of TIMI major or minor bleeding with clopidogrel treatment.

Clopidogrel prevents clotting and increases your risk of bleeding.

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However, clopidogrel showed enhanced efficacy for the reduction of ischemic events in patients with acute coronary syndromes who were carriers of the gain-of-function allele, although this effect was not observed in patients with atrial fibrillation who were carriers of the gain-of-function allele.

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PCI-CLARITY, PCI-CURE, and CREDO trials by Sabatine and colleagues demonstrated a significant reduction in the risk of cardiovascular events before and after PCI suggesting that clopidogrel pre-treatment should be started as soon as possible in patients undergoing PCI, including patients presenting with STEMI ().

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